EVENITY® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, (See More) or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.
Postmenopausal osteoporosis is a condition where your bones become thinner and weaker after menopause, which may increase your risk for fractures. Your healthcare provider can check your bone health and fracture risk. More detailed information can be found at our Osteoporosis After Menopause page.
Osteoporosis can develop for several reasons, including:
Your healthcare provider can help identify which factors apply to you.
For a deeper dive into causes and preventative steps you can take, visit the Osteoporosis After Menopause page.
After menopause, estrogen levels decrease, and your body begins to lose more bone than it creates.
Did you know?
Here are two factors that play a key role in your risk for developing osteoporosis:
You can't prevent osteoporosis, but healthy habits can help keep your bones stronger after menopause.
These include:
Your healthcare provider can recommend a plan that fits your needs. For some tips on how to get started, you can visit the Osteoporosis After Menopause page.
Estrogen helps keep a balance between bone breakdown and bone building. After menopause, lower estrogen can speed up bone loss, which is why many women’s fracture risk increases, and a need for treatment may arise to help reduce that risk. Your doctor can help you decide which treatment option is right for you.
Per the American Association of Clinical Endocrinology (AACE), a bone density test is recommended for:
The most common bone density test is called a DXA scan, a quick, noninvasive, and painless test that uses low-dose X-rays to measure the amount of minerals in your bones.
The results of a DXA scan are converted into a T-score, which represents how dense your bones are compared to the average bone density of healthy young adults.
Your doctor will assess your fracture risk by analyzing your T-score, and by taking into consideration any other risk factors you may have. If you are diagnosed with osteoporosis, your doctor will outline treatment options for you.
No, osteoporosis cannot be reversed, but its progression can be slowed. Some prescription medicines build bone while others slow bone breakdown. EVENITY is the only treatment that builds new bone and helps slow bone breakdown. Your healthcare provider can recommend options based on your fracture risk and medical history.
EVENITY is a prescription treatment for postmenopausal osteoporosis in women at high risk for fracture. It builds new bone and helps slow bone loss.
EVENITY works by blocking a protein called sclerostin, which helps shift the balance toward bone formation. For a more detailed look at EVENITY and how it works, you can visit the How EVENITY Works page.
EVENITY is given once every month for 12 months—12 doses total. For a more in-depth look at getting started on EVENITY, you can visit the How EVENITY Works page.
After finishing 12 doses of EVENITY, your healthcare provider may recommend another osteoporosis medicine to help maintain the bone density you’ve gained. For more information and to stay up to date on next steps, join the Bone Matters program today. Visit the Bone Matters Registration page.
EVENITY is for postmenopausal women with osteoporosis who are at high risk for fracture. This may include women who:
It should not be started if you’ve had a heart attack or stroke within the past year, or if you have low blood calcium that has not been corrected.
In clinical studies, EVENITY significantly reduced the risk of new spine (vertebral) fractures compared to placebo after 12 months. The benefit continued when patients transitioned to an antiresorptive therapy after 12 months. At 24 months, women who took 12 months of EVENITY followed by 12 months of Prolia® had fewer new spine fractures than women who took 12 months of placebo followed by 12 months of Prolia.
Your results may vary, so talk with your doctor about what this could mean for you. Ready for a closer look at what EVENITY can do? Visit the EVENITY Study Results page.
The most common adverse reactions (≥5%) are joint pain (arthralgia) and headache. Injection-site reactions and muscle spasms also occurred in some people. This is not a full list. For more detailed information, visit the Safety Information page. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Hair loss is not listed as a common side effect in the Prescribing Information or Medication Guide. If you notice changes, talk with your healthcare provider.
Weight gain is not listed as a common side effect in the Prescribing Information or Medication Guide. If you notice changes, talk with your healthcare provider.
The duration can vary from person to person and by side effect. Report symptoms to your healthcare provider; they can recommend monitoring or management strategies, or adjust treatment if needed.
EVENITY may increase the risk of heart attack, stroke, and cardiovascular death. It should not be started if you’ve had a heart attack or stroke within the past year. Your healthcare provider will look at your heart health and other risk factors to decide whether EVENITY is right for you. Find a Healthcare Provider
The boxed warning states that EVENITY may increase the risk of myocardial infarction (heart attack), stroke, and cardiovascular death; it should not be initiated in patients who have had MI or stroke within the preceding year, and should be discontinued if such an event occurs during treatment.
EVENITY is administered by a healthcare provider as two injections under the skin (one after the other) for a total monthly dose of 210 mg. Injections can be given in the abdomen (except 2 inches around the navel), thigh, or outer upper arm. Calcium and vitamin D supplementation is recommended during treatment.
No. EVENITY should be administered by a healthcare provider.
If a dose is missed, it should be administered as soon as it can be rescheduled. Thereafter, schedule monthly from the date of the last dose. Contact your provider to arrange the next appointment.
Out-of-pocket cost varies by insurance plan and treatment setting. Your healthcare provider’s office or insurer can estimate your cost. For more detailed information, you can visit the Paying for EVENITY page.
Coverage depends on your specific insurance. Because EVENITY is administered by a healthcare provider, it may be covered under your medical benefit. Check with your insurer for details about coverage and any prior authorization requirements.
You may be eligible for financial support programs depending on your insurance and income. Ask your provider or insurer about options. You can also contact Amgen at 1-866-264-2778 or visit amgensupportplus.com/copay to learn more.
Examples include: What is my current fracture risk? Do I need a bone density test (DXA)? Which medicines are options for me and why? What benefits and risks should I consider? How long would I take a medicine and what happens afterward? How will we monitor side effects and results? For help getting started, visit the Talking With Your Doctor page.
EVENITY may be considered if you are a postmenopausal woman with osteoporosis at high risk for fracture, or if you cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Your provider will review your cardiovascular history (including any heart attack or stroke in the past year), calcium and vitamin D status, kidney function, dental plans/procedures, and other medicines before recommending EVENITY.
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What is the most important information I should know about EVENITY?
EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem. Call your healthcare provider or get emergency help right away if you have any of these symptoms: symptoms of heart attack, which may include: chest pain or pressure; shortness of breath; feeling light-headed or dizzy; or symptoms of stroke, which may include: headache; numbness or weakness in face, arm, or legs; difficulty talking; changes in vision or loss of balance. Before you receive EVENITY, tell your healthcare provider if you have had a heart attack or stroke, especially if it has happened in the past year.
Do not receive EVENITY if you: have low blood calcium; or are allergic to romosozumab or any of the ingredients in EVENITY.
Before receiving EVENITY, tell your healthcare provider about all your medical conditions, including if you:
What are the possible side effects of EVENITY?
EVENITY may cause serious side effects, including:
Serious allergic reactions have happened in people who receive EVENITY. Call your healthcare provider or go to the nearest emergency room right away if you have any symptoms of a serious allergic reaction including: rash; hives; swelling of the face, lips, mouth, tongue, or throat which may cause difficulty in swallowing or breathing.
Low calcium levels in your blood (hypocalcemia). EVENITY may lower the calcium levels in your blood. Your low blood calcium should be treated before you receive EVENITY. Call your healthcare provider if you have symptoms of low blood calcium such as: spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes or around your mouth.
Severe jaw bone problems (osteonecrosis) may occur. Your healthcare provider should examine your mouth before you start EVENITY and may tell you to see your dentist. Ask your healthcare provider or dentist about good mouth care.
Unusual thigh bone fractures. Symptoms of this type of fracture include new or unusual pain in your hip, groin, or thigh.
The most common side effects of EVENITY include joint pain and headaches.
These are not all the possible side effects of EVENITY. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see EVENITY full Prescribing Information, including Medication Guide.
Approved Use:
EVENITY is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.
What is the most important information I should know about EVENITY?
EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem. Call your healthcare provider or get emergency help Read More